Self-destruction now becomes the logical result of those thoughts and energies. Self-hate now produces self-consumption. Fear begins to ping itself, regardless of external input. Broken faith begins to become a deal-breaker. That which a thing is, increases.
Those with choices to make on such matters should get to it, and to request spirit assistance and willingness (with grace and ease, of course). Often simply admitting such feelings will result in their release, or the beginning of their release.
As always, the most important thing you can have is a relationship with God, or one of the Great Avatars and God through that. This is most especially true if you are beginning to fall through the cracks.